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Mission

Cancer is a disease of many faces. A major challenge with this disease is treatment failure, which may occur as a result of intrinsic tumour-cell properties, or the emergence of drug-resistant clones following drug selection pressure. Through the collaborative use of omics profiling, imaging, molecular biology, pharmacology and in silico approaches, we seek to (1) define the mechanisms by which tumours respond to treatment, and (2) design therapeutic strategies that maximise tumour kill with minimal host toxicity.

Featured publications

RASAL2 confers collateral MEK/EGFR dependency in chemoresistant triple-negative breast cancer

Clinical Cancer Research, 2021

From clinical trial and preclinical specimens of breast cancer, we discovered a RAS-GTPase

activating protein, RASAL2, as a driver of chemoresistance and MEKi/EGFRi sensitivity.

About us

Research environment

We are embedded within the School of Cellular & Molecular Medicine, which hosts over 30 collaborative laboratories, outstanding core facilities and dedicated technical groups.

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