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Mission

Cancer remains challenging to treat because tumours adapt to survive diverse therapeutic and host-imposed pressures. Our laboratory seeks to uncover the adaptive programmes within tumour cells and their microenvironment that drive tumour resilience, with the goal of identifying vulnerabilities that can be targeted by the next generation of cancer therapies. By integrating advanced experimental and AI-aided computational approaches, we translate mechanistic insights into more effective and less toxic treatment strategies.

Featured publications

CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistance

Oncogene, 2025

We identified a molecular crosstalk between a RAS regulator and apoptosis that underpins chemoresistance in breast tumours.

About us

Research environment

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We are embedded within the Faculty of Health and Life Sciences, a hub of collaborative biomedical laboratories and outstanding core facilities.

© THE K  H LABORATORY

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