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Mission

Cancer is a disease of many faces. A major challenge with this disease is treatment failure, which may occur as a result of intrinsic tumour-cell properties, or the emergence of drug-resistant clones following drug selection pressure. Through the collaborative use of omics profiling, imaging, molecular biology, pharmacology and in silico approaches, we seek to (1) define the mechanisms by which tumours respond to treatment, and (2) design therapeutic strategies that maximise tumour kill with minimal host toxicity.

Featured publications

CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistance

Oncogene, 2025

We identified a molecular crosstalk between a RAS regulator and apoptosis that underpins chemoresistance in breast tumours.

About us

Research environment

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We are embedded within the Faculty of Health and Life Sciences, a hub of collaborative biomedical laboratories and outstanding core facilities.

© THE K  H LABORATORY

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